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The cybernetics of TNF: Old views and newer ones

25 Oct 2015

Abstract excerpt

The proinflammatory cytokine tumor necrosis factor (TNF) orchestrates complex multicellular processes through a wide variety of changes that it induces in cell functions. At various stages of the study of TNF, attention has been drawn to one of three different modes of its action. The work that led to the discovery of this cytokine addressed situations in which it inflicts massive damage to tissues through a mode...

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PMID: 26474540
DOI: 10.1016/j.semcdb.2015.10.014

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