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Article

Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells.

Journal of neuroinflammation - 8 Jul 2015

O'Carroll Simon J, Kho Dan Ting, Wiltshire Rachael, Nelson Vicky, Rotimi Odunayo, Johnson Rebecca, Angel Catherine E, Graham E Scott

Abstract excerpt

BACKGROUND: The vasculature of the brain is composed of endothelial cells, pericytes and astrocytic processes. The endothelial cells are the critical interface between the blood and the CNS parenchyma and are a critical component of the blood-brain barrier (BBB). These cells are innately programmed to respond to a myriad of inflammatory cytokines or other danger signals. IL-1β and TNFα are well recognised...

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Source

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Identifiers

PMID: 26152369
DOI: 10.1186/s12974-015-0346-0
PMCID: PMC4506411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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