Article
Insertion/deletion polymorphism in the BRCA2 nuclear localization signal.
Biomedical research (Tokyo, Japan) - 1 Jun 2005
Yoshikawa Yasunaga, Morimatsu Masami, Ochiai Kazuhiko, Nagano Masashi, Yamane Yoshihisa, Tomizawa Nobuyuki, Sasaki Nobuo, Hashizume Kazuyoshi
Abstract excerpt
Mutations in human BRCA2 confer an increased risk of female breast cancer. In this study, we found a novel insertion/deletion polymorphism (10204insAAA causing amino acid change M3332IK) in canine BRCA2, which is located in the putative second nuclear localization signal (NLS2) and C-terminal Rad51-binding region. The nuclear localization of the insAAA C-terminus was more efficient than localization of the delAAA...
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