Article
Trimodal GSTT1 and GSTM1 genotyping assay by real-time PCR.
The International journal of biological markers - 1 Jan 2000
Girault I, Lidereau R, Bièche I
Abstract excerpt
The GSTT1 and GSTM1 genes are characterized by the existence of a GST*0 null allele responsible for a lack of enzyme activity, with the respective null genotypes GSTT1*0/0 and GSTM1*0/0. The three resulting genotypes (GSTs*1/1, *1/0 and *0/0) are associated with a trimodal distribution of glutathione-conjugator activity. Previous epidemiological studies have only evaluated the cancer risk associated with the GST...
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