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Article

Analysis of null deletion polymorphism of glutathione S-transferase theta (GSTT-1), associated with anti-GSTT-1 antibodies development in transplantation.

International journal of immunogenetics - 1 Oct 2023

Muro-Perez Manuel, González-Martínez Gema, Martínez-García Pedro, Legaz Isabel, Zafrilla Pilar, Muro Manuel

Abstract excerpt

Glutathione S-transferase theta 1 (GSTT1) is an enzyme involved in phase II biotransformation processes and a member of a multigene family of detoxifying and clearing reactive oxygen species. GSTT1 is polymorphic like other biotransforming enzymes, allowing variability in hepatic conjugation processes. Immunological recognition of the GSTT1 alloantigen, as evidenced by donor-specific antibodies formation, has...

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PMID: 37612787
DOI: 10.1111/iji.12635

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