Article
Assessment of Bet v 1-specific CD4+ T cell responses in allergic and nonallergic individuals using MHC class II peptide tetramers.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2008
Van Overtvelt Laurence, Wambre Erik, Maillère Bernard, von Hofe Eric, Louise Anne, Balazuc Anne Marie, Bohle Barbara, Ebo Didier, Leboulaire Christophe, Garcia Gilles, Moingeon Philippe
Abstract excerpt
In this study, we used HLA-DRB1*0101, DRB1*0401, and DRB1*1501 peptide tetramers combined with cytokine surface capture assays to characterize CD4(+) T cell responses against the immunodominant T cell epitope (peptide 141-155) from the major birch pollen allergen Bet v 1, in both healthy and allergic individuals. We could detect Bet v 1-specific T cells in the PBMC of 20 birch pollen allergic patients, but also...
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