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Article

Characterization of a c-Jun-responsive module in the 5'-flank of the human CYP2J2 gene that regulates transactivation.

The Biochemical journal - 1 Nov 2005

Marden Nicole Y, Murray Michael

Abstract excerpt

The human cytochrome P450 2J2 (CYP2J2) generates cytoprotective epoxyeicosatrienoic acids from arachidonic acid. Expression of CYP2J2 is decreased in hypoxia, and the resultant decrease in CYP2J2-derived epoxyeicosanoids may contribute to the pathogenesis of cardiac ischaemia. Recent studies have indicated that AP-1 (activator protein-1) regulates CYP2J2 expression in normoxia and hypoxia. Down-regulation of...

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Share to 5' Flanking Region
Share to Cell Line, Tumor
Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Oxygenases

Share to Promoter Regions, Genetic

Share to Protein Structure, Tertiary

Share to Proto-Oncogene Proteins c-jun

Share to Transcriptional Activation

Source

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Identifiers

PMID: 16008525
DOI: 10.1042/BJ20050798
PMCID: PMC1276964

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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