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Article

Transcriptional repression of the rat steroidogenic acute regulatory (StAR) protein gene by the AP-1 family member c-Fos.

Molecular and cellular endocrinology - 25 Feb 2002

Shea-Eaton Wendy, Sandhoff Todd W, Lopez Dayami, Hales D Buck, McLean Mark P

Abstract excerpt

PGF2alpha, working via protein kinase C, may inhibit transcription of the StAR gene through negative regulatory factors. Administration of PGF2alpha increased c-Fos mRNA with a corresponding reduction in StAR mRNA. A search of the rat StAR promoter revealed three putative AP-1 elements at bp positions -85, -187 and -1561, which demonstrated specific binding of c-Fos by mobility shift assays. Co-transfection of...

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PMID: 11911955
DOI: 10.1016/s0303-7207(01)00715-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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