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Article

Regulation of the human Gi alpha-2 gene promotor activity in embryonic chicken cardiomyocytes.

Basic research in cardiology - 1 Jan 1996

Eschenhagen T, Friedrichsen M, Gsell S, Hollmann A, Mittmann C, Schmitz W, Scholz H, Weil J, Weinstein L S

Abstract excerpt

Increased expression of the inhibitory G protein Gi alpha-2 is assumed to contribute to desensitization of adenylyl cyclase in human heart failure. The mechanisms of upregulation involve increases in myocardial Gi alpha-2 protein, mRNA and gene transcriptional activity. To elucidate these mechanisms in more detail, the 5' flanking region of the human Gi alpha-2 gene (-1214/+115 bp) was cloned upstream of the...

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PMID: 8957543

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CAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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