Regulation of the human Gi alpha-2 gene promotor activity in embryonic chicken cardiomyocytes.

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Article

Regulation of the human Gi alpha-2 gene promotor activity in embryonic chicken cardiomyocytes.

Basic research in cardiology - 1 Jan 1996

Eschenhagen T, Friedrichsen M, Gsell S, Hollmann A, Mittmann C, Schmitz W, Scholz H, Weil J, Weinstein L S

Abstract excerpt

Increased expression of the inhibitory G protein Gi alpha-2 is assumed to contribute to desensitization of adenylyl cyclase in human heart failure. The mechanisms of upregulation involve increases in myocardial Gi alpha-2 protein, mRNA and gene transcriptional activity. To elucidate these mechani...

Topics

Animals
Bucladesine
Cells, Cultured
Chick Embryo
Chloramphenicol O-Acetyltransferase
Colforsin
Cyclic AMP
GTP-Binding Protein alpha Subunits, Gi-Go
Heart
Humans
Mutation
Myocardium
Plasmids
Promoter Regions, Genetic
RNA, Messenger
Transfection
Up-Regulation

Source

Open in PubMed

Identifiers

PMID: 8957543

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8957543-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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