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Article

Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of AP-1 activity.

American journal of physiology. Lung cellular and molecular physiology - 1 Aug 2008

Kumar Sanjiv, Sun Xutong, Wedgwood Stephen, Black Stephen M

Abstract excerpt

Previously, we have reported that endothelial nitric oxide synthase (eNOS) promoter activity is decreased in pulmonary arterial endothelial cells (PAECs) in response to hydrogen peroxide (H(2)O(2)). Thus the objective of this study was to identify the cis-element(s) and transcription factor(s) responsible for oxidant-mediated downregulation of the eNOS gene. Initial promoter experiments in PAECs treated with...

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Identifiers

PMID: 18556800
DOI: 10.1152/ajplung.90205.2008
PMCID: PMC2519847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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