Article
Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese.
Neurobiology of aging - 1 Dec 2010
Tan E K, Lu C S, Peng R, Teo Y Y, Wu-Chou Y H, Chen R S, Weng Y H, Chen C M, Fung H C, Tan L C, Zhang Z J, An X K, Lee-Chen G J, Lee M C, Fook-Chong S, Burgunder J M, Wu R M, Wu Y R
Abstract excerpt
The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate...
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