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Article

UCHL1 is a Parkinson's disease susceptibility gene.

Annals of neurology - 1 Apr 2004

Maraganore Demetrius M, Lesnick Timothy G, Elbaz Alexis, Chartier-Harlin Marie-Christine, Gasser Thomas, Krüger Rejko, Hattori Nobutaka, Mellick George D, Quattrone Aldo, Satoh Jun-Ichi, Toda Tatsushi, Wang Jian, Ioannidis John P A, de Andrade Mariza, Rocca Walter A, Toda Taksushi

Abstract excerpt

The reported inverse association between the S18Y variant of the ubiquitin carboxy-terminal hydrolase L1 (UCHL1) gene and Parkinson's disease (PD) has strong biological plausibility. If confirmed, genetic association of this variant with PD may support molecular targeting of the UCHL1 gene and it...

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Source

Identifiers

PMID: 15048890
DOI: 10.1002/ana.20017

Genes

UCHL1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15048890-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

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UCHL1 is a Parkinson's disease susceptibility gene.PMID 15048890Read ↗

Association between the ubiquitin carboxyl-terminal esterase L1 gene (UCHL1) S18Y variant and Parkinson's Disease: a HuGE review and meta-analysis.Semantic proximity Read ↗

Association between ubiquitin carboxy-terminal hydrolase-L1 S18Y variant and risk of Parkinson's disease: the impact of ethnicity and onset age.Semantic proximity Read ↗

Case-control study of UCHL1 S18Y variant in Parkinson's disease.Semantic proximity Read ↗

UCHL1 is associated with Parkinson's disease: a case-unaffected sibling and case-unrelated control study.Semantic proximity Read ↗

The UCHL1 S18Y polymorphism and Parkinson's disease in a Japanese population.Semantic proximity Read ↗

Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese.Semantic proximity Read ↗

S18Y in ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) associated with decreased risk of Parkinson's disease in Sweden.Semantic proximity Read ↗

UCHL-1 is not a Parkinson's disease susceptibility gene.Semantic proximity Read ↗

Lack of association between UCHL1 S18Y gene polymorphism and Parkinson's disease in the Asian population: a meta-analysis.Semantic proximity Read ↗

Case-control study of the UCH-L1 S18Y variant in sporadic Parkinson's disease in the Chinese population.Semantic proximity Read ↗

Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease.Semantic proximity Read ↗

UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan.Semantic proximity Read ↗

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