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Article

UCHL1 is associated with Parkinson's disease: a case-unaffected sibling and case-unrelated control study.

Neuroscience letters - 1 Jan 2000

Facheris Maurizio, Strain Kari J, Lesnick Timothy G, de Andrade Mariza, Bower James H, Ahlskog J Eric, Cunningham Julie M, Lincoln Sarah, Farrer Mathew J, Rocca Walter A, Maraganore Demetrius M

Abstract excerpt

To avoid the possible confounding effect of population stratification, we employed a discordant sibling study design and a liberalization of the sibling transmission disequilibrium test to confirm the association of the S18Y variant of the ubiquitin carboxi-terminal hydrolase L1 (UCHL1) gene with Parkinson's disease (PD). The study included 497 case-control pairs (427 case-unaffected sibling pairs and 70...

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Source

Identifiers

PMID: 15882803
DOI: 10.1016/j.neulet.2005.02.008

Genes

UCHL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

UCHL1 is associated with Parkinson's disease: a case-unaffected sibling and case-unrelated control study.PMID 15882803Read ↗

UCHL1 is a Parkinson's disease susceptibility gene.Semantic proximity Read ↗

Case-control study of UCHL1 S18Y variant in Parkinson's disease.Semantic proximity Read ↗

Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease.Semantic proximity Read ↗

Association between the ubiquitin carboxyl-terminal esterase L1 gene (UCHL1) S18Y variant and Parkinson's Disease: a HuGE review and meta-analysis.Semantic proximity Read ↗

Association between ubiquitin carboxy-terminal hydrolase-L1 S18Y variant and risk of Parkinson's disease: the impact of ethnicity and onset age.Semantic proximity Read ↗

Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese.Semantic proximity Read ↗

Case-control study of the UCH-L1 S18Y variant in sporadic Parkinson's disease in the Chinese population.Semantic proximity Read ↗

Mutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patients.Semantic proximity Read ↗

S18Y in ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) associated with decreased risk of Parkinson's disease in Sweden.Semantic proximity Read ↗

The UCHL1 S18Y polymorphism and Parkinson's disease in a Japanese population.Semantic proximity Read ↗

UCHL-1 is not a Parkinson's disease susceptibility gene.Semantic proximity Read ↗

A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population.Semantic proximity Read ↗

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