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Article

Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx.

Science (New York, N.Y.) - 18 Sept 1998

Chang H Y, Nishitoh H, Yang X, Ichijo H, Baltimore D

Abstract excerpt

The Fas death receptor can activate the Jun NH2-terminal kinase (JNK) pathway through the receptor-associated protein Daxx. Daxx was found to activate the JNK kinase kinase ASK1, and overexpression of a kinase-deficient ASK1 mutant inhibited Fas- and Daxx-induced apoptosis and JNK activation. Fas activation induced Daxx to interact with ASK1, which consequently relieved an inhibitory intramolecular interaction...

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Identifiers

PMID: 9743501
DOI: 10.1126/science.281.5384.1860

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx.PMID 9743501Read ↗

A kinase-independent function of Ask1 in caspase-independent cell death.Semantic proximity Read ↗

AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.Semantic proximity Read ↗

CLDN6-induced apoptosis via regulating ASK1-p38/JNK signaling in breast cancer MCF-7 cellsSemantic proximity Read ↗

Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development.Semantic proximity Read ↗

The ASK1-MAP Kinase Signaling in ER Stress and Neurodegenerative DiseasesSemantic proximity Read ↗

Apoptosis Signal Regulating Kinase 1 (ASK1): Potential as a Therapeutic Target for Alzheimer’s DiseaseSemantic proximity Read ↗

DAXX in Metabolic, Aging, and Immune Regulation: Recent InsightsSemantic proximity Read ↗

Disulfide Bond-mediated multimerization of Ask1 and its reduction by thioredoxin-1 regulate H(2)O(2)-induced c-Jun NH(2)-terminal kinase activation and apoptosis.Semantic proximity Read ↗

Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation.Semantic proximity Read ↗

Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034.Semantic proximity Read ↗

Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death.Semantic proximity Read ↗

Daxx deletion mutant (amino acids 501-625)-induced apoptosis occurs through the JNK/p38-Bax-dependent mitochondrial pathway.Semantic proximity Read ↗

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