Article
Association of GSTP1 polymorphism and survival for esophageal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2005
Lee Jang-Ming, Wu Ming-Tsang, Lee Yung-Chie, Yang Shi-Yi, Chen Jin-Shing, Hsu Hsao-Hsun, Huang Pei-Ming, Kuo Shuenn-Wen, Lee Chun-Jean, Chen Chien-Jen
Abstract excerpt
PURPOSE: Activity of glutathione S-transferase (GST) is associated with detoxification of xenobiotics and the maintenance of cell viability. Genetically variant GSTs produce different enzymatic activities. The clinical significance of this variation is still puzzling. We investigated whether genetic polymorphisms of GST including GSTP1, GSTM1, and GSTT1 affect survival among esophageal cancer patients....
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