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Article

NF-kappaB activation but not PI3K/Akt is required for dexamethasone dependent protection against TNF-alpha cytotoxicity in L929 cells.

FEBS letters - 18 Jul 2005

Mendoza-Milla Criselda, Machuca Rodríguez Catalina, Córdova Alarcón Emilio, Estrada Bernal Adriana, Toledo-Cuevas E Mayra, Martínez Martínez Eduardo, Zentella Dehesa Alejandro

Abstract excerpt

Tumor necrosis factor alpha (TNF-alpha) is one of the best-described cell death promoters. In murine L929 fibroblasts, dexamethasone inhibits TNF-alpha-induced cytotoxicity. Since phosphatidyl inositol 3 kinase (PI3K) and nuclear factor kappa B (NF-kappaB) proteins regulate several survival pathways, we evaluated their participation in dexamethasone protection against TNF-alpha cell death. We interfered with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16000198
DOI: 10.1016/j.febslet.2005.05.081

Genes

TNF
XIAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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