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Article

N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity.

Molecular and cellular biology - 1 Oct 1995

Whiteside S T, Ernst M K, LeBail O, Laurent-Winter C, Rice N, Israël A

Abstract excerpt

The proteolytic degradation of the inhibitory protein MAD3/I kappa B alpha in response to extracellular stimulation is a prerequisite step in the activation of the transcription factor NF-kappa B. Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of...

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Identifiers

PMID: 7565683
DOI: 10.1128/MCB.15.10.5339
PMCID: PMC230782

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