Article
N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity.
Molecular and cellular biology - 1 Oct 1995
Whiteside S T, Ernst M K, LeBail O, Laurent-Winter C, Rice N, Israël A
Abstract excerpt
The proteolytic degradation of the inhibitory protein MAD3/I kappa B alpha in response to extracellular stimulation is a prerequisite step in the activation of the transcription factor NF-kappa B. Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 c...
Topics
- Amino Acid Sequence
- Animals
- B-Lymphocytes
- Cell Line
- Cysteine Proteinase Inhibitors
- DNA-Binding Proteins
- Humans
- I-kappa B Proteins
- Leupeptins
- Lipopolysaccharides
- Mice
- Molecular Sequence Data
- Mutation
- NF-KappaB Inhibitor alpha
- NF-kappa B