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Article

TNF inhibited the apoptosis by activation of Akt serine/threonine kinase in the human head and neck squamous cell carcinoma.

Cellular signalling - 1 Sept 2002

Sandra Ferry, Matsuki Nori-aki, Takeuchi Hiroshi, Ikebe Tetsuro, Kanematsu Takashi, Ohishi Masamichi, Hirata Masato

Abstract excerpt

Tumour necrosis factor (TNF) is known to induce apoptosis, but recently, TNF was shown to promote cell survival, a process regulated by phosphatidylinositol-3-OH kinase (PI3K) and the NFkappaB pathway. In this study, we investigated the relationship between the molecules implicated in regulating TNF-induced cell survival and apoptosis induced by TNF in a human head and neck squamous cell carcinoma cell line...

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Source

Identifiers

PMID: 12034358
DOI: 10.1016/s0898-6568(02)00025-6

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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