Dissecting Out a Rare Mutation, STAT: Features of STAT3-Mutant Myeloid Neoplasms.

Abstract excerpt

The transcription factor STAT3 drives the expression of genes promoting cellular proliferation, survival, and pluripotency. The description of STAT3 mutations and their clinical correlates in myeloid neoplasms, such as acute myeloid leukemia and myelodysplastic syndromes, raises new insights into both the pathogenesis and the targeted therapy of these diseases. See related article by Ye et al., p. 4681.

Topics

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• Leukemia, Myeloid, Acute
• Mutation
• Myelodysplastic Syndromes
• STAT3 Transcription Factor