Article
Prevalence of drug resistance and newly recognised treatment-related substitutions in the HIV-1 reverse transcriptase and protease genes from HIV-positive patients naïve for anti-retrovirals.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Sept 2004
Torti C, Bono L, Gargiulo F, Uccelli M C, Quiros-Roldan E, Patroni A, Paraninfo G, Tirelli V, Manca N, De Francesco M A, Perandin F, Carosi G
Abstract excerpt
The aim of this study was to assess the prevalence of genetic changes in either the HIV reverse transcriptase (RT) or protease (Pro) genes in a cohort of patients naïve for anti-retroviral therapy. Of 61 patients, 43 (70.5%) were infected with HIV strains harbouring at least one resistance-related mutation, with 41 (67.2%) harbouring newly recognised treatment-related mutations. Among the 61 patients, the...
Topics
- Adult
- Anti-HIV Agents
- Drug Resistance, Viral
- Female
- HIV Infections
- HIV Protease
- HIV Protease Inhibitors
- HIV Reverse Transcriptase
- HIV-1