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NonmucoidPseudomonas aeruginosaExpresses Alginate in the Lungs of Patients with Cystic Fibrosis and in a Mouse Model

6 Jul 2005

Abstract excerpt

BACKGROUND: In patients with cystic fibrosis (CF), lung infection with mucoid Pseudomonas aeruginosa strains overexpressing the exopolysaccaride alginate is preceded by colonization with nonmucoid strains. We investigated the kinetics, impact of environmental signals, and genetics of P. aeruginosa alginate expression in a mouse model and in patients with CF. METHODS: Using indirect immunofluorescence, microarray...

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Share to Bacterial biofilms and quorum sensing
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PMID: 15995954
DOI: 10.1086/431516

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