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Article

Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis.

Infection and immunity - 1 Apr 2005

Hoffmann Nadine, Rasmussen Thomas Bovbjerg, Jensen Peter Østrup, Stub Charlotte, Hentzer Morten, Molin Søren, Ciofu Oana, Givskov Michael, Johansen Helle Krogh, Høiby Niels

Abstract excerpt

Pseudomonas aeruginosa causes a chronic infection in the lungs of cystic fibrosis (CF) patients by establishing an alginate-containing biofilm. The infection has been studied in several animal models; however, most of the models required artificial embedding of the bacteria. We present here a new pulmonary mouse model without artificial embedding. The model is based on a stable mucoid CF sputum isolate (NH57388A)...

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Source

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Identifiers

PMID: 15784597
DOI: 10.1128/IAI.73.4.2504-2514.2005
PMCID: PMC1087399

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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