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Article

Evaluation of complement factor 5 variants as genetic risk factors for the development of advanced fibrosis in chronic hepatitis C infection.

Journal of hepatology - 1 Sept 2008

Halangk Juliane, Sarrazin Christoph, Neumann Konrad, Puhl Gero, Mueller Tobias, Teuber Gerlinde, Klinker Hartwig, Hinrichsen Holger, Buggisch Peter, Landt Olfert, Weich Viola, Bergk Alexandra, Wiedenmann Bertram, Neuhaus Peter, Berg Thomas, Witt Heiko

Abstract excerpt

BACKGROUND/AIMS: Intercross studies in inbred mice susceptible or resistant to liver fibrosis revealed complement factor 5 as a quantitative trait gene associated with the development of fibrosis. In 277 patients with hepatitis C, two C5 SNPs, rs17611 and rs2300929, have been associated with advanced fibrosis. METHODS: We investigated the association of these C5 SNPs with advanced fibrosis in 1435 HCV infected...

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Identifiers

PMID: 18644651
DOI: 10.1016/j.jhep.2008.05.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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