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Article

p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B.

Molecular and cellular biology - 1 May 2005

Vadlamudi Ratna K, Barnes Christopher J, Rayala Suresh, Li Feng, Balasenthil Seetharaman, Marcus Stevan, Goodson Holly V, Sahin Aysegul A, Kumar Rakesh

Abstract excerpt

p21-activated kinase 1 (Pak1) induces cytoskeleton reorganization in part by regulating microtubule dynamics through an elusive mechanism. Using a yeast two-hybrid screen, we identified tubulin cofactor B (TCoB) (a cofactor in the assembly of the alpha/beta-tubulin heterodimers) as an interacting substrate of Pak1. Pak1 directly phosphorylated TCoB in vitro and in vivo on serines 65 and 128 and colocalized with...

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Identifiers

PMID: 15831477
DOI: 10.1128/MCB.25.9.3726-3736.2005
PMCID: PMC1084301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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