Article
Interleukin 12 (IL12B) and interleukin 12 receptor (IL12RB1) gene polymorphisms in rheumatoid arthritis.
Human immunology - 1 Jun 2005
Orozco Gisela, González-Gay Miguel A, Paco Laura, López-Nevot Miguel A, Guzmán Manuel, Pascual-Salcedo Dora, Balsa Alejandro, Martín Javier
Abstract excerpt
The aim of this study was to assess the possible association between the IL12B and the IL12RB1 gene polymorphisms and the systemic autoimmune disease rheumatoid arthritis (RA). Our study population consisted of 545 patients with RA and 393 healthy subjects. All the individuals were of white Spanish origin. Genotyping of the IL12B (IL12Bpro and IL12B 3' untranslated region) and IL12RB1 (641A-->G, 1094T-->C, and...
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