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Article

Association of interleukin-12B rs6887695 with susceptibility to allergic rhinitis.

Immunologic research - 1 Apr 2021

Falahi Sara, Salari Farhad, Rezaiemanesh Alireza, Mortazavi Seyed Hamidreza, Koohyanizadeh Farzaneh, Lotfi Ramin, Gorgin Karaji Ali

Abstract excerpt

Interleukin-12 (IL-12) is a heterodimeric cytokine encoded by two separate genes, IL12A and IL12B, which may play a regulatory role in allergen-induced inflammation through CD4+ T-cell subsets polarization. The aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) in the IL12B gene with susceptibility to allergic rhinitis (AR). We performed a case-control study including...

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PMID: 33834388
DOI: 10.1007/s12026-021-09189-1

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