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Article

Increased calbindin-D28k immunoreactivity in striatal projection neurons of R6/2 Huntington's disease transgenic mice.

Neurobiology of disease - 1 Dec 2005

Sun Z, Wang H B, Deng Y P, Lei W L, Xie J P, Meade C A, Del Mar N, Goldowitz D, Reiner A

Abstract excerpt

Striatal degeneration in Huntington's disease (HD) is associated with increases in perikaryal calbindin immunolabeling in yet-surviving striatal projection neurons. Since similar increases have also been observed in surviving striatal projection neurons after intrastriatal injection of the excitotoxin quinolinic acid, the increased calbindin in HD striatum has been interpreted to suggest an excitotoxic process in...

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Source

Identifiers

PMID: 15990326
DOI: 10.1016/j.nbd.2005.05.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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