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Article

Disruption of Purkinje cell function prior to huntingtin accumulation and cell loss in an animal model of Huntington disease.

Experimental neurology - 1 Jul 2012

Dougherty S E, Reeves J L, Lucas E K, Gamble K L, Lesort M, Cowell R M

Abstract excerpt

Huntington Disease (HD) is a devastating neurological disorder characterized by progressive deterioration of psychiatric, motor, and cognitive function. Purkinje cells (PCs), the output neurons of the cerebellar cortex, have been found to be vulnerable in multiple CAG repeat disorders, but little is known about the involvement of PC dysfunction in HD. To investigate possible PC abnormalities, we performed...

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Identifiers

PMID: 22579526
DOI: 10.1016/j.expneurol.2012.04.015
PMCID: PMC3367067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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