Article
Extracellular superoxide dismutase gene polymorphism is associated with insulin resistance and the susceptibility to type 2 diabetes.
Diabetes research and clinical practice - 1 Feb 2006
Tamai Masanori, Furuta Hiroto, Kawashima Hiromichi, Doi Asako, Hamanishi Tohru, Shimomura Hiroko, Sakagashira Setsuya, Nishi Masahiro, Sasaki Hideyuki, Sanke Tokio, Nanjo Kishio
Abstract excerpt
Oxidative stress has been implicated in pancreatic beta-cell damage, insulin resistance and vascular function in diabetic patients and the dysfunction of antioxidant enzymes may be associated with the pathogenesis of diabetes. Extracellular superoxide dismutase (EC-SOD) is found in the extracellular matrix of tissues and the major scavenger of superoxide radical. To investigate the role of genetic variability for...
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