Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Cyclin E/Cdk2 Substrate p220 <sup>NPAT</sup> Is Required for S-Phase Entry, Histone Gene Expression, and Cajal Body Maintenance in Human Somatic Cells

11 Nov 2003

Abstract excerpt

Cyclin E/Cdk2, a central regulator of the G1/S transition, coordinates multiple cell cycle events, including DNA replication, centrosome duplication, and activation of the E2F transcriptional program. Recent studies suggest a role for cyclin E/Cdk2 in activation of histone transcription during S phase via the Cajal body-associated protein p220NPAT, and in addition, p220 can promote S-phase entry independently of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Genomics and Chromatin Dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14612403
DOI: 10.1128/mcb.23.23.8586-8600.2003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Cyclin E/Cdk2 Substrate p220 <sup>NPAT</sup> Is Required for S-Phase Entry, Histone Gene Expression, and Cajal Body Maintenance in Human Somatic CellsPMID 14612403Read ↗

The cyclin E/Cdk2 substrate and Cajal body component p220(NPAT) activates histone transcription through a novel LisH-like domain.Semantic proximity Read ↗

Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription.Semantic proximity Read ↗

HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition.Semantic proximity Read ↗

Role of E2F in cell cycle control and cancerSemantic proximity Read ↗

D-Type Cyclins in Development and DiseaseSemantic proximity Read ↗

E2F and the molecular mechanisms of early cell-cycle control.Semantic proximity Read ↗

Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles.Semantic proximity Read ↗

Cyclins and related kinases in cancer cells.Semantic proximity Read ↗

Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancerSemantic proximity Read ↗

BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21Semantic proximity Read ↗

ATR enforcement of the S/G2 checkpoint prevents premature S phase shutdown and genome instabilitySemantic proximity Read ↗

SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.