Article
Distinct regions of RPB11 are required for heterodimerization with RPB3 in human and yeast RNA polymerase II.
Nucleic acids research - 1 Jan 2005
Benga Wagane J, Grandemange Sylvie, Shpakovski George V, Shematorova Elena K, Kedinger Claude, Vigneron Marc
Abstract excerpt
In Saccharomyces cerevisiae, RNA polymerase II assembly is probably initiated by the formation of the RPB3-RPB11 heterodimer. RPB3 is encoded by a single copy gene in the yeast, mouse and human genomes. The RPB11 gene is also unique in yeast and mouse, but in humans a gene family has been identified that potentially encodes several RPB11 proteins differing mainly in their C-terminal regions. We compared the...
Topics
- Amino Acid Motifs
- Amino Acid Sequence
- Cell Proliferation
- Conserved Sequence
- Dimerization
- Humans
- Molecular Sequence Data
- Mutation
- Protein Structure, Tertiary
- Protein Subunits
- RNA Polymerase II
- Saccharomyces cerevisiae Proteins
- Two-Hybrid System Techniques