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Fosl1 overexpression directly activates trophoblast-specific gene expression programs in embryonic stem cells

13 Dec 2017

Abstract excerpt

During early development in placental mammals, proper trophoblast lineage development is essential for implantation and placentation. Defects in this lineage can cause early pregnancy failures and other pregnancy disorders. However, transcription factors controlling trophoblast development remain poorly understood. Here, we utilize Fosl1, previously implicated in trophoblast giant cell development as a member of...

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PMID: 29272857
DOI: 10.1016/j.scr.2017.12.004

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