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Article

Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer.

Carcinogenesis - 1 Jan 2006

Li Donghui, Jiao Li, Li Yanan, Doll Mark A, Hein David W, Bondy Melissa L, Evans Douglas B, Wolff Robert A, Lenzi Renato, Pisters Peter W, Abbruzzese James L, Hassan Manal M

Abstract excerpt

To test the hypothesis that genetic variation in the metabolism of tobacco carcinogens, such as aromatic amines (AA) and heterocyclic amines (HCA), contributes to pancreatic cancer, we have examined genetic polymorphisms of three key enzymes, i.e. cytochrome P450 1A2 (CYP1A2) and N-acetyltransferase 1 and 2 (NAT1 and NAT2), in a hospital-based case-control study of 365 patients with pancreatic adenocarcinoma and...

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Source

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Identifiers

PMID: 15987714
DOI: 10.1093/carcin/bgi171
PMCID: PMC1350610

Genes

NAT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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