The PTPN22 C1858T variant as a risk factor for rheumatoid arthritis and systemic lupus erythematosus but not for systemic sclerosis in the Colombian population.

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The PTPN22 C1858T variant as a risk factor for rheumatoid arthritis and systemic lupus erythematosus but not for systemic sclerosis in the Colombian population.

Clinical and experimental rheumatology - 1 Jan 2000

Ramirez Martha, Quintana Gerardo, Diaz-Gallo Lina M, Caminos Jorge, Garces Maria, Cepeda Libia, Rondon Federico, Restrepo Jose F, Egea Eduardo, Garavito Gloria, Robledo Gema, Martin Javier, Iglesias-Gamarra Antonio

Abstract excerpt

OBJECTIVES: C1858T single nucleotide polymorphism in PTPN22 encoding the R620W allele variant of Lyp-PTPN22 (a protein phosphatase negatively regulating T-cell activation) has been associated with autoimmunity. This work has investigated the possible association between PTPN22 C1858T (rs2476601) polymorphism and rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) in a...

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Source

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Identifiers

PMID: 22704547

Genes

PTPN22

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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The PTPN22 C1858T variant as a risk factor for rheumatoid arthritis and systemic lupus erythematosus but not for systemic sclerosis in the Colombian population.PMID 22704547Read ↗

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