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Article

The R620W polymorphism of the protein tyrosine phosphatase 22 gene in autoimmune thyroid diseases and rheumatoid arthritis in the Tunisian population.

Annals of human biology - 1 Jan 2000

Chabchoub Ghazi, Teixiera Elisabeth Petit, Maalej Abdellatif, Ben Hamad Mariem, Bahloul Zouheir, Cornelis Francois, Ayadi Hammadi

Abstract excerpt

BACKGROUND: Protein tyrosine phosphatase (PTPN22) is involved in the negative regulation of T-cell responsiveness. The association of a coding variant of the PTPN22 gene (R620W) with a number of autoimmune diseases has been described. AIM: The present study investigated whether PTPN22 gene polymorphism was also involved in the genetic predisposition to autoimmune thyroid diseases (AITDs) and rheumatoid arthritis...

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Source

Identifiers

PMID: 19343596
DOI: 10.1080/03014460902817968

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The R620W polymorphism of the protein tyrosine phosphatase 22 gene in autoimmune thyroid diseases and rheumatoid arthritis in the Tunisian population.PMID 19343596Read ↗

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