Article
Identification of sixteen novel candidate genes for late onset Parkinson's disease.
Molecular neurodegeneration - 21 Jun 2021
Gialluisi Alessandro, Reccia Mafalda Giovanna, Modugno Nicola, Nutile Teresa, Lombardi Alessia, Di Giovannantonio Luca Giovanni, Pietracupa Sara, Ruggiero Daniela, Scala Simona, Gambardella Stefano, Iacoviello Licia, Gianfrancesco Fernando, Acampora Dario, D'Esposito Maurizio, Simeone Antonio, Ciullo Marina, Esposito Teresa
Abstract excerpt
BACKGROUND: Parkinson's disease (PD) is a neurodegenerative movement disorder affecting 1-5% of the general population for which neither effective cure nor early diagnostic tools are available that could tackle the pathology in the early phase. Here we report a multi-stage procedure to identify candidate genes likely involved in the etiopathogenesis of PD. METHODS: The study includes a discovery stage based on...
Topics
- Adult
- Age of Onset
- Aged
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Parkinson Disease
- Pedigree