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Article

Age-of-onset-dependent influence of NOD2 gene variants on disease behaviour and treatment in Crohn's disease.

BMC gastroenterology - 2 May 2013

Posovszky Carsten, Pfalzer Veronika, Lahr Georgia, Niess Jan Hendrik, Klaus Jochen, Mayer Benjamin, Debatin Klaus-Michael, von Boyen Georg B T

Abstract excerpt

BACKGROUND: Influence of genetic variants in the NOD2 gene may play a more important role in disease activity, behaviour and treatment of pediatric- than adult-onset Crohn's disease (CD). METHODS: 85 pediatric- and 117 adult-onset CD patients were tested for the three main NOD2 CD-associated variants (p.R702W, p.G908R and p.10007fs) and clinical data of at least two years of follow-up were compared regarding...

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Identifiers

PMID: 23635032
DOI: 10.1186/1471-230X-13-77
PMCID: PMC3659055

Genes

NOD2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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