Polymorphisms of tumor necrosis factor-alpha but not MDR1 influence response to medical therapy in pediatric-onset inflammatory bowel disease.

doi:10.1097/MPG.0b013e31802c41f3

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Article

Polymorphisms of tumor necrosis factor-alpha but not MDR1 influence response to medical therapy in pediatric-onset inflammatory bowel disease.

Journal of pediatric gastroenterology and nutrition - 1 Feb 2007

Cucchiara Salvatore, Latiano Anna, Palmieri Orazio, Canani Roberto Berni, D'Incà Renata, Guariso Graziella, Vieni Giuseppe, De Venuto Domenica, Riegler Gabriele, De'Angelis Gian Luigi, Guagnozzi Danila, Bascietto Cinzia, Miele Erasmo, Valvano Maria Rosa, Bossa Fabrizio, Annese Vito

Abstract excerpt

AIM: We investigated the contribution of variants of tumour necrosis factor (TNF)-alpha and MDR1 genes in the predisposition and response to medical therapy in a large pediatric cohort of patients with Crohn disease (CD) and ulcerative colitis (UC). PATIENTS AND METHODS: In this study, 200 patients with CD, 186 patients with UC, 434 parents (217 trios), and 347 healthy unrelated controls were investigated....

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PMID: 17255827
DOI: 10.1097/MPG.0b013e31802c41f3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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