Article
Genetic Determinants of Pediatric Inflammatory Bowel Disease: Is Age of Onset Genetically Determined?
1 Jan 2009
Abstract excerpt
Inflammatory bowel disease (IBD) is thought to develop as a result of dysregulation of the immune response to normal gut flora in a genetically susceptible host. Approximately 25% of incident cases of IBD occur during childhood and the rest occur throughout adulthood, peaking in the second and third decades of life. What determines the age of onset remains unexplained currently. Studying early-onset presentation...