Article
Beta-fibrinogen haplotypes and the risk for cardiovascular disease in a dialysis cohort.
American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Jul 2005
Liu Yongmei, Berthier-Schaad Yvette, Fink Nancy E, Fallin Margaret D, Tracy Russell P, Klag Michael J, Smith Michael W, Coresh Josef
Abstract excerpt
BACKGROUND: Elevated plasma fibrinogen levels are common in dialysis patients and may be related to an elevated risk for cardiovascular disease (CVD). We tested the hypothesis that genetic variation in the beta-fibrinogen ( FGB ) gene, shown to explain 1% to 5% of fibrinogen level variation in the general population, has an important role in elevated fibrinogen levels and excess CVD risk in dialysis patients....
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