Article
Transforming growth factor-beta 1 gene polymorphisms and cardiovascular disease in hemodialysis patients.
Kidney international - 1 Jul 2004
Rao Madhumathi, Guo Daqing, Jaber Bertrand L, Tighiouart Hocine, Pereira Brian J G, Balakrishnan Vaidyanathapuram S
Abstract excerpt
BACKGROUND: Atherosclerotic vascular disease is a leading cause of morbidity and mortality in patients with end-stage renal disease (ESRD) on maintenance hemodialysis (HD). Transforming growth factor-beta1 (TGF-beta1) is a multifunctional cytokine that inhibits the atheromatous process. We studied coding region polymorphisms of the TGF-beta1 gene (+869 T --> C at codon 10 and +915 G --> C at codon 25) as genetic...
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