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Article

Multidrug resistance-associated protein MRP-1 regulates dauer diapause by its export activity in Caenorhabditis elegans.

Development (Cambridge, England) - 1 Jul 2005

Yabe Tomoko, Suzuki Norio, Furukawa Tatsuhiko, Ishihara Takeshi, Katsura Isao

Abstract excerpt

Multidrug resistance-associated proteins (MRPs), when overexpressed, confer drug resistance to cancer cells by exporting anti-cancer agents through the cell membrane, but their role in animal development has not been elucidated. Here we show that an MRP homolog regulates larval development in the nematode Caenorhabditis elegans. C. elegans forms a special third-stage larva called a dauer larva under conditions...

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PMID: 15983401
DOI: 10.1242/dev.01909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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