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Article

Cmdr1, a Chicken P-Glycoprotein, Confers Multidrug Resistance and Interacts with Estradiol

1 Jan 1999

Abstract excerpt

We have cloned from a chicken intestinal cDNA library Cmdr1, the first avian P-glycoprotein. Cmdr1 is 67% and 69% identical to proteins encoded by the human MDR1 and MDR2 genes, respectively. Functional expression of Cmdr1 in both mouse NIH 3T3 and yeast cells demonstrated that Cmdr1 represents the avian ortholog of human Mdr1, since it confers resistance to several anticancer drugs and the fluorescent dye...

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PMID: 10195430
DOI: 10.1515/bc.1999.031

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