Article

Requirement for TRanslocon-Associated Protein (TRAP) α in insulin biogenesis

2019-01-26

Abstract excerpt

The mechanistic basis for the biogenesis of peptide hormones and growth factors is poorly understood. Here we show that the conserved endoplasmic reticulum (ER) membrane translocon-associated protein (TRAP) α, also known as signal sequence receptor 1 (SSR1) 1 , plays a critical role in the biosynthesis of insulin. A genetic screen in the nematode Caenorhabditis elegans revealed trap-1 , which encodes the C. el...

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Literature Corpus work: 2a9bc7b1-cdda-5531-9f0e-71a6689cc1d0
DOI: 10.1101/531491

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