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Article

Identification of genes regulated by nanog which is involved in ES cells pluripotency and early differentiation.

Journal of cellular biochemistry - 15 Aug 2008

Liu Na, Feng Xiaoming, Fang Zhihong, Ma Fengxia, Lu Shihong, Lu Min, Han Zhongchao

Abstract excerpt

Nanog plays an important role in embryonic stem (ES) cells pluripotency and self-renewal, yet the precise mechanism through which Nanog accomplishes this important function remains unclear. To understand comprehensive molecular mechanism by which Nanog mediates, we identified genome-wide molecular changes upon silencing Nanog in ES cells by using microarray technology. In order to downregulate Nanog expression...

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PMID: 18442017
DOI: 10.1002/jcb.21795

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