Article
BRAF mutation and RASSF1A expression in thyroid carcinoma of southern Italy.
Journal of cellular biochemistry - 1 May 2013
Santoro Angela, Pannone Giuseppe, Carosi Maria Antonia, Francesconi Arianna, Pescarmona Edoardo, Russo Giuseppe Maria, Feola Antonia, Losito Simona, Franco Renato, Nappi Luigi, Aquino Gabriella, De Rosa Gaetano, Di Domenico Marina, Bufo Pantaleo
Abstract excerpt
Aim of this work is to provide a detailed comparison of clinical-pathologic features between well-differentiated and poorly differentiated tumors according to their BRAF and RASSF1A status. We analyzed RASSF1A methylation by MSP and BRAF mutation by LCRT-PCR with LightMix® kit BRAF V600E in neoplastic thyroid tissues. Immunohistochemical evaluation of RASSF1A expression was also performed by standard automated...
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