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Article

Hypermethylated RASSF1 and SLC5A8 promoters alongside BRAFV600E mutation as biomarkers for papillary thyroid carcinoma.

Journal of cellular physiology - 1 Oct 2020

Khatami Fatemeh, Larijani Bagher, Heshmat Ramin, Nasiri Shirzad, Haddadi-Aghdam Mohammad, Teimoori-Toolabi Ladan, Tavangar Seyed M

Abstract excerpt

Circulating cell-free DNA (cfDNA) has been considered as a diagnostic source to track genetic and epigenetic alterations in cancer. We aimed to study mutation in addition to the methylation status in the promoter regions of RASSF1 and SLC5A8 genes in tissues and circulating free DNA samples of patients affected with papillary thyroid carcinoma (PTC) and thyroid nodules as controls. BRAFV600E mutation was studied...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32017063
DOI: 10.1002/jcp.29591

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