Article
Determination of major UDP-glucuronosyltransferase enzymes and their genotypes responsible for 20-HETE glucuronidation.
Journal of lipid research - 1 Nov 2014
Jarrar Yazun Bashir, Cha Eun-Young, Seo Kyung-Ah, Ghim Jong-Lyul, Kim Hyo-Ji, Kim Dong-Hyun, Lee Su-Jun, Shin Jae-Gook
Abstract excerpt
The compound 20-HETE is involved in numerous physiological functions, including blood pressure and platelet aggregation. Glucuronidation of 20-HETE by UDP-glucuronosyltransferases (UGTs) is thought to be a primary pathway of 20-HETE elimination in humans. The present study identified major UGT enzymes responsible for 20-HETE glucuronidation and investigated their genetic influence on the glucuronidation reaction...
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