Article
Transcriptome analysis of human hepatic and pancreatic stellate cells: organ-specific variations of a common transcriptional phenotype.
Journal of molecular medicine (Berlin, Germany) - 1 Oct 2005
Buchholz Malte, Kestler Hans A, Holzmann Karlheinz, Ellenrieder Volker, Schneiderhan Wilhelm, Siech Marco, Adler Guido, Bachem Max G, Gress Thomas M
Abstract excerpt
Pancreatic stellate cells (PSCs) are thought to be the primary source of the extensive fibrotic reaction characteristic of pancreatic cancer and chronic pancreatitis in humans. PSCs share many morphological and functional characteristics with hepatic stellate cells (HSCs), whose central role in liver fibrosis is well established. However, it has remained unclear if hepatic and pancreatic stellate cells are...
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