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Article

Tris+/Na+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region.

The Journal of general physiology - 1 Apr 1992

Cohen B N, Labarca C, Czyzyk L, Davidson N, Lester H A

Abstract excerpt

Tris+/Na+ permeability ratios were measured from shifts in the biionic reversal potentials of the macroscopic ACh-induced currents for 3 wild-type (WT), 1 hybrid, 2 subunit-deficient, and 25 mutant nicotinic receptors expressed in Xenopus oocytes. At two positions near the putative intracellular end of M2, 2' (alpha Thr244, beta Gly255, gamma Thr253, delta Ser258) and -1', point mutations reduced the relative...

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Identifiers

PMID: 1597678
DOI: 10.1085/jgp.99.4.545
PMCID: PMC2219204

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