Article
Tris+/Na+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region.
The Journal of general physiology - 1 Apr 1992
Cohen B N, Labarca C, Czyzyk L, Davidson N, Lester H A
Abstract excerpt
Tris+/Na+ permeability ratios were measured from shifts in the biionic reversal potentials of the macroscopic ACh-induced currents for 3 wild-type (WT), 1 hybrid, 2 subunit-deficient, and 25 mutant nicotinic receptors expressed in Xenopus oocytes. At two positions near the putative intracellular...
Topics
- Amino Acid Sequence
- Animals
- Biological Transport
- Cell Membrane Permeability
- DNA
- Mathematics
- Membrane Potentials
- Mice
- Molecular Sequence Data
- Mutation
- Oocytes
- Receptors, Nicotinic
- Sodium
- Torpedo
- Tromethamine
- Xenopus